The staff is run by Harvard College students across multiple disciplines.
The reboot of The Harvard Brain was founded by Amanda Yang '22 in 2020. 

​Editor-in-Chief:
Amanda Yang '22

​Writing Editors:
William Drew '21
Bhargavi Garimella '23
Andrew Ham '22
​Audrey Jones '22
Christine Lee '23
Isabella Trasolini '23
Esther Yu '22

​Webmaster/Media:
Esther Yu '22